Paclitaxel is extracted from natural plant pacltitaxel bark monomer pairs of terpenoids, secondary metabolites is a complex, also is a kind of can promote now know only microtubule polymerization and stable microtubule polymerization of drugs. Isotope tracer showed that paclitaxel combined with only the aggregation of microtubules, not with aggregation of tubulin dimers. Cells after contact with paclitaxel in intracellular accumulation of a large number of microtubules, the accumulation of these microtubules interfere with cell functions, in particular to arrest at mitotic cell division, blocking the normal cell division. Through the - clinical research, paclitaxel is mainly suitable for ovarian cancer and breast cancer, to lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma, brain tumors also has certain curative effect.
Paclitaxel Function:
1. Paclitaxel is a mitotic inhibitor drup used in the treatment of cancer.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
3. Paclitaxel has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
4. Paclitaxel is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.
Paclitaxel Application:
1. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis.
2. Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes
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