Isavuconazole

CAS No.:241479-67-4

Other Names:Isavuconazole

MF:C22H17F2N5OS

Type:Antibiotic and Antimicrobial Agents

Grade Standard:Medicine Grade

Model Number:API

Purity:95%

Supply Ability

10000 Kilogram/Kilograms per Week

Packaging & Delivery

Packaging Details

Standard Package

Port :any port in China

Lead Time :within 10days after the payment

Product Description

 Isavuconazole
 

Isavuconazole ( 4-{2-[(1R,2R)-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1,3-thiazol-4-yl}benzonitrile) is a triazole antifungal drug. Its prodrug, isavuconazonium sulfate (BAL8557), was granted approval by the U.S. Food and Drug Administration (FDA) on March 6, 2015.

Isavuconazole works by inhibiting lanosterol 14 alpha-demethylase, the enzyme responsible for converting lanosterol to ergosterol by demethylation. The resulting depletion of ergosterol and build up of lanosterol compromise the structure of the fungal cell membrane. Mammalian cells are resistant to demethylation inhibition by azoles, making the drug effects specific to fungi.

Identified: 

  Ø  CAS No.:  241479-67-4 

Properties: 

  Ø  Molecular Weight: 437.47

  Ø  Molecular Formula:  C₂₂H₁₇F₂N₅OS

  Ø   Storage: Shading, sealed, dry place.

  Ø  Appearance:  white powder

 Applications:

   Ø  Pharmaceutical API