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2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile
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Ceritinib

 

 

 

CAS No.: 1032900-25-6

Other Names:LDK378

MF:C28H36ClN5O3S

Place of Origin:CHINA

Type:Antineoplastic Agents

Grade Standard:Medicine Grade

Purity:99.5% MIN

Appearance:Off-white powder

Water:0.5% MAX

Residue on ignition:0.3% MAX

Heavy Metal Melting Point:10PPM MAX

Melting Point:173~179°C

Packaging & Delivery

Packaging Details

option to customer

Port : any port in China 

Ceritinib

1.Specification:

Product name

Ceritinib/LDK378

CAS

1032900-25-6

Package

Option to customer

Stock

Fresh

Molecular Structure

 Ceritinib 1032900-25-6.png

Molecular Formula

C28H36ClN5O3S

Molecular Weight

558.14

 

2.Detailed Product Description: (COA)

Items

The Standard Result

Appearance

Off-white powder

Identification

H-NMR, MS

Water

£0.5%

Residue on ignition

£0.3%

Heavy Metal

≤10ppm

Melting Point

173~179°C

 

 

Residual Solvents

Iisopropanol£5000ppm

Ethyl acetate£5000ppm

Ethanol£5000ppm

DIPEA £5000ppm

 

 

 

 

 

Related substances

Impurity A £0.1%

Impurity B £0.1%

Impurity C£0.1%

Impurity D £0.1%

Impurity F £0.1%

Impurity G £0.1%

 

 

Microbial limit

Microbial count£1000 cfu/g

Total combined moulds and yeasts count£1000cfu/g

Escherichia coli absent

Related Impurity by HPLC

Max Single impurity ≤0.1 %

Total impurity ≤0.5%

Purity (HPLC)

³ 99.5%

3.Function and usage

Ceritinib (INN) is a drug for the treatment of a specific type of lung cancer. It is an anaplastic lymphoma kinase (ALK) inhibitor. It was developed by Novartis. It was approved in April 2014 by the Food and Drug Administration for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC) in patients that failed treatment with crizotinib. It is a more effective, but more toxic, alternative to traditional platinum-based chemotherapies. Ceritinib was found at physiological concentrations to inhibit ALK, insulin-like growth factor 1 receptor (IGF-1R), and ROS1.

4.Payment:

Terms:100%Pay in advanced, T/T, Western Union or PayPal are OK or Kindly indicate

5.Delivery:

In about 15 working days after the receipt of payment, we will follow up the delivery until you receive it.(Shipping : TNT,Fedex,DHL,USP,EMS and so on)

6. Packaging: 

Drum&plastic bags, Aluminum foiled bag, Zip lock bags


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