Erlotinib intermediates manufacturer
Product name: Afatinib (BIBW 2992)
Cas Number: 439081-18-2
Moculer formula: C24H25ClFN5O3
Moculer weigh: 485.944
Certification of 439081-18-2
Appearance |
White to off-white powder |
Complies |
Identification |
H-NMR |
Complies |
Purity(by HPLC) |
Not less than 99.0% |
99.47% |
Loss on dry |
Not more than 0.5% |
0.25% |
Single impurity |
Not more than 1.0% |
0.32% |
Conclusion |
The batch complies with In-house standard.
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More information of 439081-18-2
It is a small molecule tyrosine kinase inhibitor. It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) modelsand has shown partial responses in clinical trials with renal cell carcinoma (RCC) and several other tumour types.
Application of 439081-18-2
It was approved for RCC by the U.S. Food and Drug Administration after showing a modest increase in progression-free survival.
